Taipei, Taiwan 10 - 13 Nov, 2006
taipei101とHyatホテル
Taipei, Taiwan 10 - 13 Nov, 2006
taipei101とHyatホテル
PHASE II TRIAL OF GEMCITABINE AND PACLITAXEL COMBINATION CHEMOTHERAPY IN THE TREATMENT OF PATIENTS WITH RELAPSED OR REFRACTORY NON-SMALL CELL LUNG CANCER: West-Japan Thoracic Oncology Group (WJTOG0103DI)
T. Sawa, N.Katakami, H.Nishimura, K.Matsui, T.Seto, M.Fukuoka
Gifu Municipal Hospital, West-Japan Thoracic Oncology Group, Osaka, Japan
PURPOSE: A phase II trial was carried out to evaluate the efficacy and toxicity of combination chemotherapy of gemcitabine (GEM) and paclitaxel (PAC) in the treatment of patients with relapsed or refractory non-small cell lung cancer (NSCLC).
METHOD: Fifty-five patients with relapsed or refractory NSCLC who had received treatment with one or two previous regimen with platinum or docetaxel entered this multi-institutional clinical trial. All patients had been assigned to CR/PR group or NC/PD group by the response of previous last chemotherapy. All patients received GEM 1000 mg/m2 on day 1, 8 and PAC 150 mg/m2 on days 1 of each 21-day cycle and repeated more than 3 cycles.
RESULTS: Patients were reevaluated for response after each cycle of therapy; those with objective response or stable disease continued treatment for three courses or until disease progression. In the 20 patients of CR/PR group, four of 19 valuable patients (21%) had partial responses to treatment while one of 33 valuable patients (3%) in the 35 patients of NC/PD group. Median survival was 16 and 11 months in the CR/PR and NC/PD group respectively. Treatment was generally well tolerated; myelosuppression was the major toxicity, but only one patient developed pneumonitis, and resulted treatment-related deaths.
CONCLUSION: The activity of GEM and PAC in patients with previously treated NSCLC is modest and is limited to patients with relapsed (chemotherapy-sensitive) disease. In patients with relapsed NSCLC treated with platinum or docetaxel, it is thought that this regimen provides an additional treatment option, with decreased toxicity when compared to other second-line options.
Keywords: gemcitabine, paclitaxel, non-small cell lung cancer
学会開会式には陳水扁首相自ら出席し，オープニングスピーチを行いました．
台北観光といえば故宮博物院ですが，中国本国から運んできた紀元前の青銅器，明清時代の陶磁器など歴史的展示品は
すばらしいです．（展示品は大英博物館のような他国から略奪したものではなく，すべて中国のものです）
夕方，”台北のベニス”？？と呼ばれる淡水に行ってきました．地下鉄で30分程度です．ベニスかどうかはともかく
家族連れ，アベックなど大勢の台湾の市民でごった返していました．河岸の店は，日本のお祭りの縁日のような雰囲気です．
淡水の街のはずれにある紅毛城，オランダ，英国統治時代の要塞跡です．
高台にあり，ここで夕日が沈むのを見るのがアベックの常番コースのようです．
賑やかな夜市の様子．どこから来たかと思う人の人波です．新宿，渋谷，銀座などと比べものにならない人でした．
週末は人が歩道から溢れ，幹線道路は麻痺状態になります．地下鉄で行くのがベストです．
taipei101の91階屋外展望台（400ｍ）からみた，真下の国際会議場とhyatホテル
Gara Dinnerは台北グランドホテル（台北料理の美味しい伝統ホテルです）で開かれ，台湾太鼓の競演
（和太鼓とよく似てます）や，鼓を紐で操る妙技が披露されました．
台湾は，全般に治安がよく，国に勢いがある（発展している！）という印象です．原付スクーターがむやみに多いこと
以外は，日本人にあまり違和感のないところです．台湾のドクターも多くがフレンドリーでした．