Istanbul, Turky- 29 Sep - 3 Oct, 2006
連絡船から眺めた新市街ドルマバフチェ宮殿とオルタキョイジャーミー．道路は渋滞しているため連絡船の方が早い場合があります．海峡沿いの街へいくには，連絡船の方が安くて時間が確実でした．
Combination chemotherapy with gemcitabine and paclitaxel in the treatment of patients with relapsed or refractory non-small cell lung cancer: multi-institutional phase II trial of West Japan Thoracic Oncology Group (WJTOG0103DI)
T. Sawa, N.Katakami, H.Nishimura, K.Matsui, T.Seto, Y.Nakanishi, M.Fukuoka, S.Negoro
Gifu Municipal Hospital, West-Japan Thoracic Oncology Group
Purpose: A phase II trial was carried out to evaluate the efficacy and toxicity of combination chemotherapy of gemcitabine (GEM) and paclitaxel (PAC) in the treatment of patients with relapsed or refractory non-small cell lung cancer (NSCLC).
Method: Fifty-five patients with relapsed or refractory NSCLC who had received treatment with one or two previous regimen with platinum or docetaxel entered this multi-institutional clinical trial. All patients had been assigned to CR/PR group or NC/PD group by the response of previous last chemotherapy. All patients received GEM 1000 mg/m2 on day 1, 8 and PAC 150 mg/m2 on days 1 of each 21-day cycle and repeated more than 3 cycles.
Results: Patients were reevaluated for response after each cycle of therapy; those with objective response or stable disease continued treatment for three courses or until disease progression. In the 20 patients of CR/PR group, four of 19 valuable patients (21%) had partial responses to treatment while one of 33 valuable patients (3%) in the 35 patients of NC/PD group. Median survival was 16 and 11 months in the CR/PR and NC/PD group respectively. Treatment was generally well tolerated; myelosuppression was the major toxicity, but only one patient developed pneumonitis, and resulted treatment-related deaths.
Conclusion: The activity of GEM and PAC in patients with previously treated NSCLC is modest and is limited to patients with relapsed (chemotherapy-sensitive) disease. In patients with relapsed NSCLC treated with platinum or docetaxel, it is thought that this regimen provides an additional treatment option, with decreased toxicity when compared to other second-line options.
国際会議センターよりボスフォラス海峡を望む
安ホテルの裏窓からみたボスフォラス海峡（景色は一級）
ガラタ塔から眺めた旧市街の夜景
ベリーダンスショー夜21時から0時まで繰り広げられる
トプカピ宮殿のモザイク
トプカピ宮殿の庭園から金角湾を望む
トプカピ宮殿にて（ハーレムの入り口：時間がなく見学できず）
ドルマバフチェ宮殿にて（宮殿内はガイドツアーのみのため2時間かかりました）
学会の合間に半日しか市内を見ていませんが，写真でみる様子と違い「喧騒と雑踏の街」という印象でした．道路事情がよくない割に1800万人が生活しています．とにかくタクシーのドライバーがクラクションを鳴らしながらビュンビュン飛ばすのは，映画の世界のようでした．あと，やたらと日本語で声をかけてくる客引きが多いのは残念でした．逆に日本語を話せない人たちはとても親切でした．時々爆弾テロがあるせいか，会議場や観光施設は空港なみのセキュリティーチェックがありますので，中はかえって安心でした．